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In order to find the right vials and therefore the right closures for an application, there are a number of points to consider. On the one hand, the type of autosampler or the syringe of the autosampler is decisive. The wrong closures can quickly lead to a defect in the syringe. On the other hand, the sample is of course also decisive. There may be an incompatibility between the sample and the vial or septum. A distinction should also be made between short-term and long-term storage. Another point is the sensitivity of the sample to light. All these things should be taken into account in order to identify the appropriate vials and septa.