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InertSustainâ„¢ (U)HPLC Columns manufactured by GL-Sciences are based on a new type of silica, termed as "Evolved Surface Silica", which provides both high inertness and high durability. The surface of the silica is uniquely modified, enabling precise control of the silica properties. InertSustain inherits the advantages of all the current Inertsil HPLC columns (e.g. extremely low operating back pressure, superior inertness to typically any analytes, high efficiency and compatibility with a wide range of solvents), but now can be used for wide pH analysis with consistent performance from column to column and lot to lot. In 2021 GL-Sciences added the InertSustain AX-C18 as the newest member to the InertSustain family. The column combines C18- and aminogroups being a mixed-mode column mostly suitable for the analysis of acidic compounds.