GL Sciences / Bioptic

Bioptic

Bioptic® HPLC columns are designed for the simple analysis of bioactive substances (e.g. drugs or metabolites) from plasma samples. The base material is a spherical silica gel modified with avidin molecules via a special alkyl spacer linkage. Bioptic AV columns allow the inner hydrophobic surface of the silica to be shielded by a permanently bonded hydrophilic avidin layer. Large molecules like plasma proteins are excluded from interacting with the hydrophobic inner surface by the avidin layer, and elute by size-exclusion mechanisms in the void volume. Smaller compounds, such as drugs and drug metabolites, pass through the avidin layer and interact with the hydrophobic inner layer by a reverse-phase mechanism.

 

Bioptic AV-1 contains non-denatured avidin and a chiral center, allowing separation of chiral drugs and their metabolites. Bioptic AV-2 contains a denatured form of avidin and lacks the chiral separating ability of AV-1, but offers different selectivity.

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Technical Data

Phase name

Modification

Particle size

Pore size

End-capping

C-content

USP

Surface area

pH range

Tmax

Bioptic® AV-1

Avidin

5 µm

N/A

N/A

N/A

N/A

N/A

2.0-7.5*

40°C

Bioptic® AV-2

Avidin (denaturated)

5 µm

N/A

N/A

N/A

N/A

N/A

2.0-7.5*

40°C

* pH Ranges for hydrophobic interactions: pH 2-3.5 and pH 6-7.5

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