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Bioptic
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Bioptic® HPLC columns are designed for the simple analysis of bioactive substances (e.g. drugs or metabolites) from plasma samples. The base material is a spherical silica gel modified with avidin molecules via a special alkyl spacer linkage. Bioptic AV columns allow the inner hydrophobic surface of the silica to be shielded by a permanently bonded hydrophilic avidin layer. Large molecules like plasma proteins are excluded from interacting with the hydrophobic inner surface by the avidin layer, and elute by size-exclusion mechanisms in the void volume. Smaller compounds, such as drugs and drug metabolites, pass through the avidin layer and interact with the hydrophobic inner layer by a reverse-phase mechanism.
Bioptic AV-1 contains non-denatured avidin and a chiral center, allowing separation of chiral drugs and their metabolites. Bioptic AV-2 contains a denatured form of avidin and lacks the chiral separating ability of AV-1, but offers different selectivity.
Product Line
- Inertsil
- InertSustain
- InertSustain Swift
- InertCap
- InertSep
- Titansphere
- LD239 Gas Leak Detector
- GF-1010 Digital Gas Flow Meter
- Bioptic
- GL Sciences-HayeSep
- GL Sciences-Porapak
- GL Sciences-TC
- GL Sciences-Tenax
- GL Sciences-Unibeads
- InertCore
- InertSep WAX FF/GCB
- InertSphere
- MonoCap
- MonoFas
- MonoSpin
- MonoTrap
- OPTIC
- ProteoSil
- SYPRON
Technical Data
| Phase name | Modification | Particle size | Pore size | End-capping | C-content | USP | Surface area | pH range | Tmax |
| Bioptic® AV-1 | Avidin | 5 µm | N/A | N/A | N/A | N/A | N/A | 2.0-7.5* | 40°C |
| Bioptic® AV-2 | Avidin (denaturated) | 5 µm | N/A | N/A | N/A | N/A | N/A | 2.0-7.5* | 40°C |
* pH Ranges for hydrophobic interactions: pH 2-3.5 and pH 6-7.5
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