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Tailing peaks, altered retention times, pressure fluctuations or missing detector signal - these and many more are all cases that are undesirable in the everyday life of the analyst, but nevertheless occur from time to time.
In order to help you with troubleshooting, some manufacturers have produced very helpful brochures on the subject of troubleshooting, which give you a good overview of possible sources of error and how to rectify them in everyday HPLC work.
We are happy to answer any questions and provide support on the subject of troubleshooting.