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SPE reagents are special chemical compounds used in solid phase extraction to improve the selectivity and efficiency of the extraction. These include buffer solutions, acids, bases and organic solvents that are used to prepare the sample for SPE, elute the target analytes and remove interfering substances. The selection of the correct reagents is based on the physico-chemical properties of the substances to be extracted and the matrix of the sample. These reagents play a crucial role in achieving high purity and yield of the target compounds.