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ProPac 3R
The ProPac 3R product line consist of two ion exchange columns (SCX and SAX). These columns are especially designed for protein and monoclonal antibody (mAb) analysis. The housing material is bioinert PEEK. The particles are monodisperse, non-porous 3µm divinylbenzene resins. The monodisperse particles have a consistent size distribution, resulting in improved packing and lot-to-lot reproducibility.
Technical Data
What distinguishesd the ProPac 3R columns?
The 3Rs in the name of the product line stand for robustness, reproducibility and resolution.
Robustness:
- Bio-inert materials to reduce secondary interactions
- Compatible with aqueous, high-ionic strength mobile phases
- Broad range of pH (2-12), temperature (up to 60°C), mobile phase compositions and MS friendly
Run-to-run reproducibility of Left: protein G salt gradient analysis on a ProPac 3R SAX column Right: NISTmAb salt gradient analysis on a ProPac 3R SCX column
Reproducibility:
- Outstanding column-to-column reproducibility
- High lot-to-lot reproducibility
Lot-to-lot reproducibility of Left: protein G salt gradient separation on a ProPac 3R SAX column Right: NISTmAb salt gradient separation on a ProPac 3R SCX column
Resolution:
- Monodisperse particles enhance resolution
- Improved peak-to-valley resolution of charge variants
Salt gradient analysis of Links: protein G using a ProPac 3R SSX column Rechts: infliximab using a ProPac 3R SCX column
When do you benefit from the ProPac 3R family?
- Higher resolution compared to other IEX columns
Comparison of Left: Protein G separation on Propac 3R SAX, 3µm and a ProPac SAX 10µm columns using high-resolution 30-minute gradient method. Right: NISTmAb separation on MAbPac SCX-10, 10µm 4 x 250mm. ProPac 3R SCX, 3µm 4 x 100mm, and a competitor's SCX 3µm 4.6 x 100mm column using a high-resolution 25-minute gradient method.
- Easy selection of suitable column
Conclusion: The ProPac 3R IEX columns offer high resolution compared to other columnsdue to monodisperse 3µm particles. They are highly reproducible and robust,making them an outstanding product line for analysis of proteins and mAbs.
As an official distributor of ThermoScientific, you can get the new ProPac 3R product range directly from us. We would be happy to advise youon the selection of the best column for your application. Please contact our support team for a consultation and an individual offer. We are looking forward to your contact!
Downloads
Brochures
Thermo ProPac 3R Brochure
Technical Support
Thermo ProPac 3R SAX Product Manual
Thermo ProPac 3R SCX Product Manual
Thermo ProPac 3R Quick Start Guide
Applications
Thermo Propac 3R SAX Salt Gradient AAV Analysis Application
Thermo Propac 3R SAX Salt Gradient Protein G Analysis Application
Thermo ProPac 3R SCX pH Gradient mAb Analysis Application
Thermo ProPac 3R SCX Salt Gradient mAb Analysis Application
The right column for you - we will be happy to support you individually
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Certificates of analysis, MSDS, data sheets