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MabPac
MAbPac™ is a family of HPLC columns, manufactured by Thermo Scientific™, for efficient analysis of monoclonal antibodies and their fragments and aggregates using different separation techniques.
MAbPac™ RP is an HPLC column for high resolution accurate mass determination of monoconal antibody variants, antibody drug conjugates (ADC) and proteins by reversed-phase chromatography. The columns are based on polyvinylbenzene and exhibit superior pH and temperature stability.
MAbPac™ SEC-1 is a size exclusion chromatography (SEC) column specifically designed for the high-resolution separation and characterization of monoclonal antibodies (mAbs) and their aggregates. The separation range for globular proteins is about 10.000 to 1.000.000 g/mol.
The MAbPac™ HIC column family is designed for separations of monoclonal antibodies (mAb´s) and related biologics by Hydrophobic Interaction Chromatography (HIC). The base material for MAbPac™ HIC-10 and HIC-20 is porous silica gel and for MAbPac™ HIC-butyl it is a hydrophilic polymer.
MAbPac™ SCX-10 is a strong cation exchange column designed specifically for the high-resolution, high efficiency charged variant analysis of monoclonal antibodies and associated variants. MabPac™ SCX-10 RS is designed for higher flow rates and high throughput analysis.
MAbPac™ Protein A is an affinity column designed to provide fast monoclonal antibody (mAb) titer analysis. The column is based on a non-porous polymeric resin consisting of a divinylbenzene core and a hydrophilic surface. The recombinant Protein A ligands are covalently attached onto the hydrophilic resin surface. The binding capacity is about 3.5 mg IgG/g Resin.
Technical Data
| Phase-Name | Modification | Particle Size | Pore Size | End-capping | C-Content | USP | Surface | pH-Range | Tmax |
| MAbPac™ RP | - | 4 µm | 1500 Å | - | N/A | N/A | N/A | 0.0‒14.0 | 110 °C |
| MAbPac™ SEC-1 | Diol | 5 µm | 300 Å | N/A | N/A | N/A | N/A | 2.5‒7.5 | 30 °C |
| MAbPac™ HIC-10 | Proprietary Polyamide | 5 µm | 1000 Å | N/A | N/A | N/A | 20 m2/g | 2.0‒8.0 | 60 °C |
| MAbPac™ HIC-20 | Proprietary Amide | 5 µm | 1000 Å | N/A | N/A | N/A | 20 m2/g | 2.0‒9.0 | 60 °C |
| MAbPac™ HIC-Butyl | Butyl | 5 µm | Non-porous | N/A | N/A | N/A | N/A | 2.0‒12.0 | 60 °C |
| MAbPac™ SCX-10 | Sulfonic acid | 3, 5, 10 µm | Non-porous | N/A | N/A | N/A | N/A | 2.0‒12.0 | 60 °C |
| MAbPac™ SCX-10 RS | Sulfonic acid | 5 µm | Non-porous | N/A | N/A | N/A | N/A | 2.0‒12.0 | 60 °C |
| MAbPac™ Protein A | Protein A | 12 µm | Non-porous | N/A | N/A | N/A | N/A | 2.5‒7.5 | 30 °C |
Downloads
Brochures
Thermo MAbPac HIC HPLC Life Science Brochure
Thermo MAbPac Protein A HPLC Life Science Brochure
Thermo MAbPac RP HPLC Life Science Brochure
Thermo MAbPac SCX 10 HPLC Life Science Brochure
Thermo MAbPac SEC 1 SEC Life Science Brochure
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