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Thermo Scientific™ Aquasil™ HPLC columns are polar endcapped octadecyl phases with an alternative selectivity compared to conventional C18 phases. The phases show increased retention of polar compounds and are compatible with 100% aqueous mobile phases. The base material is a high-purity, spherical, base-deactivated silica gel with particle sizes of 3 or 5 μm. The columns are suitable for LC-MS applications.