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Opalshell™-C18 are the latest columns from Sepax based on the solid-core technology. As the stationary phase, silica particles are used which consist of a solid non-porous core surrounded by a porous silica layer. The advantages of this technology are high separation efficiencies, which are in the range of fully porous sub-2 μm particles but have a low back pressure in the region of the fully porous material of the same size.