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DNACore columns from NanoChrom have been specially developed for the high-resolution separation of oligonucleotides, including mRNA and plasmids. These columns are based on monodisperse particles and special column chemistry, resulting in high resolution, ideal selectivity and good stability. Various columns for reverse phase, ion exchange and size exclusion chromatography are available for analysis.
Phase | Modification | matrix | Particle size | Pore size | Application | Tmax | pH range |
DNACore 1000 C18 | C18 | monodisperse silica | 5 µm | 1000 Å | Purity analysis of oligonucleotides, short-chain oligos, DNA, mRNA, plasmids, etc. | 60 °C | 2.0 - 11.0 |
DNACore NP-Q | quaternary ammonium | monodisperse PS/DVB | 5 µm | non-porous | Content analysis of the plasmid topology | 80 °C | 2.0 - 12.0 |
DNACore SEC-1000 | diol | monodisperse Silica | 3 µm | 1000 Å | Aggregate and fragment analysis in mRNAs and plasmids | 40 °C | 2.0 - 8.0 |
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