NanoChrom Technologies (Suzhou) Co., Ltd

BioCore

Biocore and BioCore SEC columns from NanoChrom are specially developed columns for analysing antibodies, proteins and biological samples in general. These columns are equipped with various modifications in order to fulfil as many applications as possible.

BioCore SEC columns are for size exclusion chromatography to identify monomers, aggregates or single chains.

BioCore IEX columns can be used to distinguish charge variants in antibodies or proteins.

BioCore HIC-Butyl can be used to separate antibodies and antibody conjugates due to different hydrophobicity.

BioCore RP-Butyl is a non-porous material for the exact determination of masses of antibodies and proteins.

BioCore Glycan are special HILIC columns to analyse N-glycans in proteins and antibodies.

BioCore Protein A has a modification for affinity chromatography for rapid titer analysis of monoclonal antibodies (mAb) and Fc fusion proteins.

Product Line

Technical Data

BioCore SEC

[English:]

Phase	Modification	Particle size	Pore size	Molecular area (PEG)	Molecular area (glucan)	Molecular area (protein)	Tmax	pH range
BioCore SEC-120	Diol	1.8, 3, 5 µm	120 Å	300 - 10,000 Da	N/A	N/A	40 °C	2.0 - 8.0
BioCore SEC-150	Diol	1.8, 3, 5 µm	150 Å	500 - 15,000 Da	1,000 - 30,000 Da	5,000 - 150,000 Da	40 °C	2.0 - 8.0
BioCore SEC-300	Diol	1.8, 3, 5 µm	300 Å	1,000 - 50,000 Da	2,000 - 100,000 Da	10,000 - 750,000 Da	40 °C	2.0 - 8.0
BioCore SEC-500	Diol	1.8, 3, 5 µm	500 Å	5,000 - 200,000 Da	20,000 - 500,000 Da	20,000 - 1,500,000 Da	40 °C	2.0 - 8.0

BioCore IEX

Phase	Modification	Particle size	Pore size	matrix	Tmax	pH range
BioCore WCX	Caboxylate	5, 10 µm	non-porous	PS/DVB	60 °C	2.0 - 12.0
BioCore SCX	sulphonate	5, 10 µm	non-porous	PS/DVB	60 °C	2.0 - 12.0
BioCore WAX	tertiary amines	5, 10 µm	non-porous	PS/DVB	60 °C	2.0 - 12.0
BioCore SAX	quaternary ammonium	5, 10 µm	non-porous	PS/DVB	60 °C	2.0 - 12.0

BioCore HIC

Phase	Modification	Particle size	Pore size	Tmax	pH range
BioCore HIC-Butyl	C4	5 µm	1000 Å	60 °C	2.0 - 8.0

BioCore RP

Phase	Modification	Particle size	Pore size	matrix	Tmax	pH range
BioCore RP-Butyl	C4	5 µm	non-porous	PS/DVB	100 °C	2.0 - 12.0

BioCore Glycan

Phase	Modification	Particle size	Pore size	Tmax	pH range
BioCore Glycan	polyamide	3 µm	180 Å	80 °C	2.0 - 9.0

BioCore Protein A

Phase	Modification	Particle size	Pore size	matrix	Binding capacity	temperature	pH range
BioCore Protein A	pH stable rProtein A	15 µm	1000 Å	PS/DVB	≥20 mg/ml (IgG)	2 - 40 °C	2.0 - 12.0

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