Checkout using your account
Checkout as a new customer
Creating an account has many benefits:
- See order and shipping status
- Track order history
- Check out faster
Cosmosil 1.8C18-MS-II
The COSMOSIL 1.8C18-MS-II columns from Nacalai Tesque are new fully porous columns for UHPLC applications. The small 1.8µm particles allow a high number of theoretical plates and thus good separations even with short columns. Due to the high hydrophobicity of the COSMOSIL 1.8C18-MS-II columns, even demanding separations of hydrophobic analytes can be separated. The columns are designed for MS detection and are therefore available in 2.1mm inner diameter and in lengths of 30, 50, 75, 100 and 150mm.
Product Line
Technical Data
| Phase | Modification | Particle size | Pore size | Surface area | Max. Pressure | pH |
| COSMOSIL 1.8C18-MS-II | C18 | 1.8 µm | 120 Å | 340 m²/g | 800 bar | 2.0-10.0 |
Applications
What characterises the COSMOSIL 1.8C18-MS-II columns?
Durability test COSMOSIL 1.8C18-MS-II 50x2.1mm
- Excellent service life of the pillar
Column: COSMOSIL 1.8C18-MS-II 50x2.1mm
Mobile Phase A: 0.1% TFA in Water
Mobile Phase B: 0.1% TFA in Acetonitrile
Gradient:
| Time / min | %B |
| 0-3.00 | 5-90 |
| 3.00-3.01 | 90-5 |
| 3.01-6.00 | 5 |
Flow rate: 0.4 mL/min
Temperature: 40 °C
Detection: UV 236 nm
Sample: Amitriptyline (0.2 mg/mL)
Injection volume: 1.0 µL
Separation of structural isomers of vitamin D (COSMOSIL 1.8C18-MS-II 50x2.1mm)
- Available particle sizes range up to 15µm; simple scaling for preparative processes
Peak Identities
1. Previtamin D3
2. Vitamin D3
3. Lumisterol
4. 7-Dehydrocholesterol (7-DHC)
When will you benefit from the COSMOSIL 1.8C18¬-MS-II?
Drugs (NSAIDs) COSMOSIL 1.8C18-MS-II 50x2.1mm
- Strong hydrophobic properties of the phase allow the separation of challenging analytes
Peak Identities
1. Acetylsalicyclic acid 2. Loxoprofen 3. Ketoprofen 4. Naproxen 5. Phenylbutazone 6. Celecoxib 7. Diclofenac 8. Indometacin
Flavonoid analysis (COSMOSIL 1.8C18-MS-II 50x2.1mm)
- Phase selectivity can enable difficult separations that co-elute on other columns
Peak Identities
1. Myricetin 2. 7,8-Dihydroxyflavone 3. Quercetin 4. Apigenin 5. Kaempferol 6. 7-Hydroxyflavone 7. 6-Hydroxyflavone 8. Flavone 9. Chrysin 10. 6-Methoxyflavone 11. 3-Hydroxyflavone 12. 5-Hydroxyflavone
Conclusion: With the COSMOSIL 1.8C18-MS-II phase, hydrophilic substances can be optimally separated and at the same time an alternative selectivity to other C18 columns is possible. The availability of particle sizes of up to 15µm makes the scale-up process easy to manage.
Downloads
Brochures
Nacalai Tesque Cosmosil1.8C18-MS-II Brochure
The right column for you - we will be happy to support you individually
Competent consultants are always at your side. Write a message to our consultants, we will get back to you and give you individual support.
You will find:
Application support
Availability and delivery times
Price information with individual conditions
Certificates of analysis, MSDS, data sheets