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Astec Chiraldex
Astec Chiraldex® are special GC columns, manufactured by Merck-Supelco™ (Sigma-Aldrich™) for the separation of enantiomers. The phases are based on differently modified cyclodextrins as the chiral selector.
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Technical Data
Astec Chiraldex® A-TA:
- High selectivity for oxygen containing analytes in the form of alcohols, ketones, acids, aldehydes and lactones
- It is also highly selective for halogenated compounds.
Astec Chiraldex® B-TA:
- High selectivity for oxygen containing analytes in the form of alcohols, ketones, acids, aldehydes and lactones
- It is also highly selective for halogenated compounds.
Astec Chiraldex® G-TA:
- Highest selectivity for oxygen-containing analytes like alcohols, diols and polyols, amino acids, hydroxy acids, amines as acyl derivatives, amino alcohols, halogens (Cl>Br>F), lactones, furans and pyrans.
- This phase has been shown to be the most broadly-selective phase for the pharmaceutical industry, especially for the analysis of chiral intermediates and drug studies in various stages of clinical trials.
Astec Chiraldex® G-PN:
- High selectivity for lactones and aromatic amines. It is also suitable for epoxide separations.
- Additionally, the analysis of styrene oxide can be accomplished on this phase (this analyte degrades on the TA phases).
Astec Chiraldex® B-DP:
- Good hydrolytic stability, broad chiral selectivity
- Excellent for aliphatic and aromatic amines
- Also good for many aliphatic and some aromatic esters
Astec Chiraldex® G-DP:
- Enhanced selectivity for both aliphatic and aromatic amines, in additional to aliphatic and some aromatic esters
- Especially useful for polar racemates
- Better hydrolytic and thermal stability than the Chiraldex® G-TA
Astec Chiraldex® G-BP:
- High selectivity for amino acids, amines, and furans
Astec Chiraldex® B-DM:
- Useful for a number of free acids and bases
- Able to perform most of the separations done on a beta permethylated phase, but with higher resolution
- The selectivity of the B-DM covers applications of both the B-PM and B-PH phases, although with superior performance.
Astec Chiraldex® G-DM:
- Broad chiral selectivity, resolving aliphatic, olefenic, and aromatic enantiomers.
- It combines the selectivities of the PM and PH phases
Astec Chiraldex® B-PM:
- General-purpose column used for the separation of acids, alcohols, barbitals, diols, epoxides, esters, hydrocarbons, ketones, lactones and terpenes.
- Also, some underivatized alcohols and diols as well as some analytes with polar groups, i.e. tertiary amines, show excellent separation.
Astec Chiraldex® A-DA:
- Good for separations of heterocyclic amines
- It has different selectivity from other phases and often shows reversal in elution from the PH phases
Astec Chiraldex® B-DA:
- Chiraldex® B-DA requires that analytes possess a minimum of two ring structures, one of which is unsaturated (aromatic) α, β to the stereogenic center. Examples include fluoxetine, methylphenidate and chloropheniramine.
- Effective for multi-ring analytes
Astec Chiraldex® G-DA:
- Good for separations of heterocyclic amines
- It has different selectivity from other phases and often shows reversal in elution from the PH phases
Astec Chiraldex® B-PH:
- Show at least some selectivity to a great variety of analytes
- Effective for saturated analytes with minimal functionality, saturated cyclics and bicyclics
- This phase often shows a reversal of elution order (enantioreversal) compared to the B-DA phase
| Column-Name | Chiral Selector | I.D. | Film thickness | Tmax |
| Chiraldex® A-TA | 2,6-Di-O-pentyl-3-trifluoroacetyl Derivat of α-Cyclodextrin | 0.25 mm | 0.12 µm | 180 °C |
| Chiraldex® B-TA | 2,6-Di-O-pentyl-3-trifluoroacetyl Derivat of β-Cyclodextrin | 0.25 mm | 0.12 µm | 180 °C |
| Chiraldex® G-TA | 2,6-Di-O-pentyl-3-trifluoroacetyl Derivat of γ-Cyclodextrin | 0.25 mm | 0.12 µm | 180 °C |
| Chiraldex® G-PN | 2,6-Di-O-pentyl-3-propionyl Derivat of γ-Cyclodextrin | 0.25 mm | 0.12 µm | 200‒220 °C |
| Chiraldex® B-DP | 2,3-Di-O-propionyl-6-t-butyl silyl Derivat of β-Cyclodextrin | 0.25 mm | 0.12 µm | 200‒220 °C |
| Chiraldex® G-DP | 2,3-Di-O-propionyl-6-t-butyl silyl Derivat of γ-Cyclodextrin | 0.25 mm | 0.12 µm | 200‒220 °C |
| Chiraldex® G-BP | 2,6-Di-O-pentyl-3-butyryl Derivat of γ-Cyclodextrin | 0.25 mm | 0.12 µm | 200‒220 °C |
| Chiraldex® B-DM | 2,3-Di-O-methyl-6-t-butyl silyl Derivat of β-Cyclodextrin | 0.25 mm | 0.12 µm | 200‒220 °C |
| Chiraldex® G-DM | 2,3-Di-O-methyl-6-t-butyl silyl Derivat of γ-Cyclodextrin | 0.25 mm | 0.12 µm | 200‒220 °C |
| Chiraldex® B-PM | 2,3,6-Tri-O-methyl Derivat of β-Cyclodextrin | 0.25 mm | 0.12 µm | 200‒220 °C |
| Chiraldex® A-DA | 2,6-Di-O-pentyl-3-methoxy Derivat of α-Cyclodextrin | 0.25 mm | 0.12 µm | 200‒220 °C |
| Chiraldex® B-DA | 2,6-Di-O-pentyl-3-methoxy Derivat of β-Cyclodextrin | 0.25 mm | 0.12 µm | 200‒220 °C |
| Chiraldex® G-DA | 2,6-Di-O-pentyl-3-methoxy Derivat of γ-Cyclodextrin | 0.25 mm | 0.12 µm | 200‒220 °C |
| Chiraldex® B-PH | (S)-2-Hydroxy propyl methyl ether Derivat of β-Cyclodextrin | 0.25 mm | 0.12 µm | 200‒220 °C |
[1] Dependent on film thickness and whether you work at constant temperature or with a gradient.
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Applications
Merck Supelco Applications-Notebook Vol2 GC, GC-MS, SPME, Air Monitoring
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