Monolithic Columns

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Monolithic Columns

Unlike other columns,monolithic columns do not consist of individual particles. Instead, they consist of a single rod of highly porous material. This porous material has macropores and mesopores. The macropores allow the mobile phase to flow through the material at low back pressure (pore size >1 µm). The mesopores are narrower and enable high-performance separation (pore size 100-300 Å). Monolithic columns are available as monoliths based on silica and on organic polymers.

What are the advantages of monolithic columns?

Low back pressure at high flow rates - shortens the analysis time
Column efficiency does not decrease significantly at higher flow rates
Columns last longer than fully porous particle columns due to low back pressure
Monolithic columns are very robust
High matrix tolerance - no complex sample preparation required

Which manufacturers offer monolithic columns?

1. Merck (Supelco)

With the Chromolith series, Merck offers monolithic silica-based columns. They are available in different pore sizes (macro- and mesopores) and various modifications. The dimensions range from capillary columns to preparative dimensions.

2. Thermo Scientific

Thermo Scientific offers monolithic columns based on organic polymers for various bio-applications. The ProSwift and PepSwift series are available in various modifications and dimensions.

MZ-Analysentechnik gives you access to the monolithic columns from the manufacturers Merck and ThermoFisher. We will be happy to provide you with a customised quotation for your requirements or simply visit our online shop directly.

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