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Chromolith
Merck´s Chromolith® HPLC columns are based on monolithic silica. In contrast to conventional particle-packed columns, Chromolith® phases are produced from a continuous piece of porous silica using a sol-gel process. The stationary phase possess a defined bimodal pore structure with macro- and mesopores in the micro- and nanometer range. The high permeability and porosity of the silica skeleton and the resulting low back pressure allow for more flexible flow rates compared to particulate columns. As a result, Chromolith® HPLC columns enable high-throughput analysis without loss of separation efficiency or peak capacity.
Chromolith® HPLC columns comes in different sizes from capillary to preparative.
Technical Data
| Phase name | Modification | Particle size | Pore size[1] | End-capping | C-content | USP | Surface area | pH range | Tmax |
| Chromolith® RP-18 e | C18 | Monolithic | 13 nm / 2 µm | + | 18% | L1 | 300m2/g | 2.0-7.5 | 45 °C |
| Chromolith® HR RP-18 e | C18 | Monolithic | 15 nm / 1.15 µm | + | 18% | L1 | 250m2/g | 2.0-7.5 | 45 °C |
| Chromolith® RP-8 e | C8 | Monolithic | 13 nm / 2 µm | + | 11% | L7 | 300m2/g | 2.0-7.5 | 45 °C |
| Chromolith® HR RP-8 e | C8 | Monolithic | 15 nm / 1.15 µm | + | 11% | L7 | 250m2/g | 2.0-7.5 | 45 °C |
| Chromolith® Phenyl | Propylphenyl | Monolithic | 13 nm / 2 µm | N/A | 11% | N/A | 300m2/g | 2.0-7.5 | 45 °C |
| Chromolith® CN | Cyano (CN) | Monolithic | 13 nm / 2 µm | N/A | 11% | N/A | 300m2/g | 2.0-7.5 | 45 °C |
| Chromolith®NH2 | Aminopropyl | Monolithic | 13 nm / 2 µm | - | N/A | N/A | 300m2/g | 2.0-7.5 | 45 °C |
| Chromolith® Diol | Diol | Monolithic | 13 nm / 2 µm | N/A | 11% | N/A | 300m2/g | 2.0-7.5 | 45 °C |
| Chromolith® Si | - | Monolithic | 13 nm / 2 µm | N/A | - | L3 | 300m2/g | 2.0-7.5 | 45 °C |
[ 1] For Chromolith® 2 mm i.d. columns tde macropores have an average pore size of 1.5 µm
Chromolith WP 300 columns for bioapplications with 300Å mesopores
| Phase name | Modification | Particle size | Pore size[1] | End-capping | C-content | USP | Surface area | pH range | Tmax |
| Chromolith® WP-300 RP-18 | C18 | Monolithic | 30 nm / 2 µm | N/A | 8-9% | N/A | 120m2/g | 1.5-7.5 | 45 °C |
| Chromolith® WP-300 RP-8 | C8 | Monolithic | 30 nm / 2 µm | N/A | 4-5% | N/A | 120m2/g | 1.5-7.5 | 45 °C |
| Chromolith® WP-300 RP-4 | C4 | Monolithic | 30 nm / 2 µm | N/A | 3-4% | N/A | 120m2/g | 1.5-7.5 | 45 °C |
| Chromolith® WP-300 Protein A | Protein A | Monolithic | 30 nm / 2 µm | N/A | N/A | N/A | 120m2/g | N/A | N/A |
| Chromolith® WP-300 Epoxy[1] | Epoxy | Monolithic | 30 nm / 2 µm | N/A | 5-6% | N/A | 120m2/g | N/A | N/A |
[ 1 ] For Chromolith® 2 mm i.d. columns the macropores have an average pore size of 1.5 µm
Downloads
Brochures
Merck ChromBook Catalogue 2015
Merck Chromolith Brochure
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