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Nucleosil
Nucleosil® is a family of totally porous spherical silicas, manufactured by Macherey-Nagel. They feature a very pure and uniform SiO2 structure and have gained wide acceptance as routine chromatographic packings for very different fields of modern chromatography. Nucleosil® was developed in the 1970s and was one of the first spherical silicas used in HPLC. Nowadays it is a world-renowned HPLC packing. The phases are available with many different modifications.
Technical Data
| Phase-Name | Modification | Particle Size | Pore Size | End-capping | C-Content | USP | Surface | pH-Range | Tmax |
| Nucleosil® C18 | C18 | 5 µm
| 50 Å
| + | 14.5%
| L1 | 420 m2/g
| 2.0‒8.0 | N/A |
| Nucleosil® C18 AB | C18 | 5 µm | 100 Å | + | 25% | L1 | 350 m2/g | 1.0‒9.0 | N/A |
| Nucleosil® C18 HD | C18 | 3, 5 µm | 100 Å | + | 20% | L1 | 350 m2/g | 2.0‒9.0 | N/A |
| Nucleosil® 100-5 C18 PAH | C18 | 5 µm | 100 Å | N/A | N/A | L1 | 350 m2/g | N/A | N/A |
| Nucleosil® C8 | C8 | 5, 7, 10 µm
| 100 Å
| - | 8.5%
| L7 | 350 m2/g
| 2.0‒8.0 | N/A |
| Nucleosil® C8 ec | C8 | 5 µm | 100 Å | + | 9% | L7 | 350 m2/g | 2.0‒8.0 | N/A |
| Nucleosil® C8 HD | C8 | 5 µm | 100 Å | + | 13% | L7 | 350 m2/g | 2.0‒8.0 | N/A |
| Nucleosil® C4 | C8 | 5 µm | 120 Å
| + | 4%
| L26 | 200 m2/g
| 2.0‒8.0 | N/A |
| Nucleosil® C2 | Dimethyl | 7 µm | 100 Å | - | 3.5% | L16 | 350 m2/g | 2.0‒8.0 | N/A |
| Nucleosil® C6H5 | Phenylpropyl | 5, 7 µm | 100 Å | - | 8% | L11 | 350 m2/g | 2.0‒8.0 | N/A |
| Nucleosil® CN/CN-RP | Cyanopropyl | 5, 10 µm
| 100 Å
| - | 5%
| L10 | 350 m2/g
| 2.0‒8.0 | N/A |
| Nucleosil® NH2/ NH2-RP | Aminopropyl | 3, 5, 10 µm | 100 Å | - | 3.5% | L8 | 350 m2/g | 2.0‒8.0 | N/A |
| Nucleosil® OH | Diol | 5 µm | 100 Å | - | N/A | L20 | 350 m2/g | 2.0‒8.0 | N/A |
| Nucleosil® C18 Nautilus | Polar embedded C18 | 3, 5 µm | 100 Å | + | 16% | L60 | 350 m2/g | 2.0‒8.0 | N/A |
| Nucleosil® Protect I | Polar embedded Alcyl | 5 µm | 100 Å | + | 11% | N/A | 350 m2/g | 2.0‒8.0 | N/A |
| Nucleosil® SB | ‒N+(CH3)3 Cl− | 5, 10 µm | 100 Å | - | 10% | L14 | 350 m2/g | 2.0‒8.0 | N/A |
| Nucleosil® Anion II | Quaternary Ammonium | 10 µm | 300 Å | N/A | N/A | N/A | 100 m2/g | 2.0‒7.5 | N/A |
| Nucleosil® N(CH3)2 | Diethylamino | 5 µm | 100 Å | - | 4% | N/A | 350 m2/g | 2.0‒8.0 | N/A |
| Nucleosil® SA | Benzenesulfonic acid | 5, 10 µm | 100 Å | - | 6,5% | L9 | 350 m2/g | 2.0‒8.0 | N/A |
| Nucleosil® MPN | C18 | 5 µm | 100 Å
| N/A | N/A | L1
| 350 m2/g
| 2.0‒8.0 | N/A |
| Nucleosil® PPN | C18 | 5 µm | 100 Å
| N/A | N/A | L1 | 350 m2/g
| 1.0‒9.0 | N/A |
| Nucleosil® Carbohydrate | Amino | 10 µm | N/A | N/A | N/A | L8 | N/A | N/A | N/A |
| Nucleosil® CHIRAL-1 | L-Hydroxyproline Cu2+ complex | 5 µm | 120 Å | N/A | N/A | L32 | 200 m2/g | N/A | N/A |
| Nucleosil® CHIRAL-2 | N-(3,5-Dinitrobenzoyl)-D-phenylglycin | 5 µm | 100 Å | N/A | N/A | L36 | 350 m2/g | N/A | N/A |
| Nucleosil® CHIRAL-3 | N-(3,5-Dinitrobenzoyl)-L-phenylglycin | 5 µm | 100 Å | N/A | N/A | L36 | 350 m2/g | N/A | N/A |
| Nucleosil® SiOH | - | 5 µm | 50 Å
| - | - | L3 | 450 m2/g
| 2.0‒8.0 | N/A |
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